(4R-CIS)-1,1-DIMETHYLETHYL-6-[2-[2-(4-FLUOROPHENYL)-5-(1-METHYLETHYL)-3-PHENYL-4-[(PHENYLAMINO) CARBONYL]-1H-PYRROL-1-yl]ETHYL]-2,2-DIMETHYL-1,3-DIOXANE-4-ACETATE (ATORVASTATINE CONDENSATION PRODUCT

(4R-CIS)-1,1-DIMETHYLETHYL-6-[2-[2-(4-FLUOROPHENYL)-5-(1-METHYLETHYL)-3-PHENYL-4-[(PHENYLAMINO) CARBONYL]-1H-PYRROL-1-yl]ETHYL]-2,2-DIMETHYL-1,3-DIOXANE-4-ACETATE (ATORVASTATINE CONDENSATION PRODUCT | L-1) - Names and Identifiers

Name	(4R-CIS)-1,1-DIMETHYLETHYL-6-[2-[2-(4-FLUOROPHENYL)-5-(1-METHYLETHYL)-3-PHENYL-4-[(PHENYLAMINO) CARBONYL]-1H-PYRROL-1-yl]ETHYL]-2,2-DIMETHYL-1,3-DIOXANE-4-ACETATE (ATORVASTATINE CONDENSATION PRODUCT \| L-1)
Synonyms	L-1 L-1(for Atorvastatin) AtorvastatinCalcium(L-1) Atorvastatin Calcium Intermediate L1 3-ethyl-5-(2-hydroxyethyl)-4-methyl-1,3-thiazol-3-ium bromide tert-Butyl 2-[(4R,6R)-6-[2-[2-(4-fluorophenyl)-5-isopropyl-3-phenyl-4-(phenylcarbamoyl)-1H-pyrrol-1-yl] tert-Butyl (4R,6R)-6-[2-[2-(4-fluorophenyl)-5-isopropyl-3-phenyl-4-(phenylcarbamoyl)-1-pyrrolyl]ethyl]-2,2-dimethyl-1,3-dioxane-4-acetate tert-butyl (4r,6r)-2-[[[6-(2-4-fluorophenyl)-5-isopropyl-3-phenyl-4-(phenylcarbamoyl)pyrrol-1-yl]ethyl]-2,2-dimethyl-1,3-dioxan-4-yl]acetate (4R-cis)-1,1-dimethylethyl-6-[2-[2-(4-fluorophenyl)-3-phenyl-4-[(phenylamino)carbonyl]-1H-pyrrol-1-yl]ethyl]-2,2-dimethyl-1,3-dioxane-4-acetate tert-butyl [(4R,6R)-6-{2-[2-(4-fluorophenyl)-3-phenyl-4-(phenylcarbamoyl)-5-(propan-2-yl)-1H-pyrrol-1-yl]ethyl}-2,2-dimethyl-1,3-dioxan-4-yl]acetate (4R-CIS)-1,1-DIMETHYLETHYL-6-[2-[2-(4-FLUOROPHENYL)-5-(1-ISOPROPYL)-3-PHENYL-4-[(PHENYLAMINO)CARBONYL]-1H-PYRROL-1-YL]ETHYL]-2,2-DIMETHYL-1,3-DIOXANE-4-ACETATE (4R-CIS)-[1,1-DIMETHYLETHYL-6-[(2-FLUOROPHENYL)-5-(1-METHYLETHYL)-3-PHENYL-4-[(PHENYLAMINO) CARBONYL]-1H-PYRROL-1-YL]ETHYL]-2, 2-DIMETHYL-1, 3-DIOXANE-4-ACETATE (4R-cis)-1,1-Dimethylethyl- 6-[2-[2-(4-fluorophenyl)-5-(1-isopropyl)-3-phenyl-4-[(phenylamino)carbonyl]-1H-pyrrol-1-yl]ethyl]-2,2-dimethyl-1,3-dioxane-4-acetate L-1(4R-Cis)-1,1-DiMethylethyl-6- 2- 2-(4-Fluorophenyl)-5-(1-Isopropyl)-3-Phenyl-4 (PhenylaMino)carbonyl -1H-pyrrol-1-yl Ethyl -2,2-DiMethyl-1,3-Dioxane-4-Acetate (4r,6r)-6-[2-[2-(4-fluorophenyl)-5-(1-methylethyl)-3-phenyl-4-[(phenylamino)carbonyl]-1h-pyrrol-1-yl]ethyl]-2,2-dimethyl-1,3-dioxane-4-acetic acid 1,1-dimethylethyl ester (4R-CIS)-6-[2-[2-(4-FLUOROPHENYL)-5-(1-METHYLETHYL)-3-PHENYL-4-[(PHENYLAMINO)CARBONYL]-1H-PYRROL-1-YL]ETHYL]-2,2-DIMETHYL-1,3-DIOXANE-4-ACETIC ACID, 1,1-DIMETHYLETHYL ESTER (4R-cis)-1,1-dimethylethyl-6-[2-[2-(4-fluorophenyl)-3-phenyl-4-(4R-cis)-1,1-dimethylethyl-6-[2-[2-(4-fluorophenyl)-3-phenyl-4-[(phenylamino)carbonyl]-1H-pyrrol-1-yl]ethyl]-2,2-dimethyl-1,3-dioxane-4-acetate
CAS	125971-95-1
EINECS	258-925-2
InChI	InChI:1S/C40H47FN2O5/c1-26(2)36-34(27-14-10-8-11-15-27)35(38(45)42-30-16-12-9-13-17-30)37(28-18-20-29(41)21-19-28)43(36)23-22-31-24-32(47-40(6,7)46-31)25-33(44)48-39(3,4)5/h8-21,26,31-32H,22-25H2,1-7H3,(H,42,45)
InChIKey	NPPZOMYSGNZDKY-ROJLCIKYSA-N

(4R-CIS)-1,1-DIMETHYLETHYL-6-[2-[2-(4-FLUOROPHENYL)-5-(1-METHYLETHYL)-3-PHENYL-4-[(PHENYLAMINO) CARBONYL]-1H-PYRROL-1-yl]ETHYL]-2,2-DIMETHYL-1,3-DIOXANE-4-ACETATE (ATORVASTATINE CONDENSATION PRODUCT | L-1) - Physico-chemical Properties

Molecular Formula	C40H47FN2O5
Molar Mass	654.81
Density	1.14±0.1 g/cm3(Predicted)
Melting Point	144-148°C(lit.)
Boling Point	678.0±55.0 °C(Predicted)
Specific Rotation(α)	6.5 º (c=1, chloroform)
Solubility	Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly)
Appearance	Solid
Color	White
pKa	13.57±0.70(Predicted)
Storage Condition	Refrigerator

(4R-CIS)-1,1-DIMETHYLETHYL-6-[2-[2-(4-FLUOROPHENYL)-5-(1-METHYLETHYL)-3-PHENYL-4-[(PHENYLAMINO) CARBONYL]-1H-PYRROL-1-yl]ETHYL]-2,2-DIMETHYL-1,3-DIOXANE-4-ACETATE (ATORVASTATINE CONDENSATION PRODUCT | L-1) - Risk and Safety

Safety Description	24/25 - Avoid contact with skin and eyes.
UN IDs	UN 2811 6.1 / PGII
WGK Germany	3
HS Code	29349990

(4R-CIS)-1,1-DIMETHYLETHYL-6-[2-[2-(4-FLUOROPHENYL)-5-(1-METHYLETHYL)-3-PHENYL-4-[(PHENYLAMINO) CARBONYL]-1H-PYRROL-1-yl]ETHYL]-2,2-DIMETHYL-1,3-DIOXANE-4-ACETATE (ATORVASTATINE CONDENSATION PRODUCT | L-1) - Reference Information

biological activity	Atorvastatin acetonide tert-butyl ester is an effective intermediate for the preparation of Atorvastatin salts. Atorvastatin is an oral HMG-CoA reductase inhibitor, which can effectively reduce blood lipids.
use	atorvastatin calcium intermediate

Last Update：2024-04-09 21:04:16

(4R-CIS)-1,1-DIMETHYLETHYL-6-[2-[2-(4-FLUOROPHENYL)-5-(1-METHYLETHYL)-3-PHENYL-4-[(PHENYLAMINO) CARBONYL]-1H-PYRROL-1-yl]ETHYL]-2,2-DIMETHYL-1,3-DIOXANE-4-ACETATE (ATORVASTATINE CONDENSATION PRODUCT | L-1)

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(4R-CIS)-1,1-DIMETHYLETHYL-6-[2-[2-(4-FLUOROPHENYL)-5-(1-METHYLETHYL)-3-PHENYL-4-[(PHENYLAMINO) CARBONYL]-1H-PYRROL-1-yl]ETHYL]-2,2-DIMETHYL-1,3-DIOXANE-4-ACETATE (ATORVASTATINE CONDENSATION PRODUCT | L-1)
硬脂基二甲铵羟丙基水解角蛋白
Chloral acetochloroform

(4R-CIS)-1,1-DIMETHYLETHYL-6-[2-[2-(4-FLUOROPHENYL)-5-(1-METHYLETHYL)-3-PHENYL-4-[(PHENYLAMINO) CARBONYL]-1H-PYRROL-1-yl]ETHYL]-2,2-DIMETHYL-1,3-DIOXANE-4-ACETATE (ATORVASTATINE CONDENSATION PRODUCT | L-1)

(4R-CIS)-1,1-DIMETHYLETHYL-6-[2-[2-(4-FLUOROPHENYL)-5-(1-METHYLETHYL)-3-PHENYL-4-[(PHENYLAMINO) CARBONYL]-1H-PYRROL-1-yl]ETHYL]-2,2-DIMETHYL-1,3-DIOXANE-4-ACETATE (ATORVASTATINE CONDENSATION PRODUCT | L-1)

CAS: 125971-95-1

Molecular Formula: C40H47FN2O5

(4R-CIS)-1,1-DIMETHYLETHYL-6-[2-[2-(4-FLUOROPHENYL)-5-(1-METHYLETHYL)-3-PHENYL-4-[(PHENYLAMINO) CARBONYL]-1H-PYRROL-1-yl]ETHYL]-2,2-DIMETHYL-1,3-DIOXANE-4-ACETATE (ATORVASTATINE CONDENSATION PRODUCT | L-1) - Names and Identifiers

(4R-CIS)-1,1-DIMETHYLETHYL-6-[2-[2-(4-FLUOROPHENYL)-5-(1-METHYLETHYL)-3-PHENYL-4-[(PHENYLAMINO) CARBONYL]-1H-PYRROL-1-yl]ETHYL]-2,2-DIMETHYL-1,3-DIOXANE-4-ACETATE (ATORVASTATINE CONDENSATION PRODUCT | L-1) - Physico-chemical Properties

(4R-CIS)-1,1-DIMETHYLETHYL-6-[2-[2-(4-FLUOROPHENYL)-5-(1-METHYLETHYL)-3-PHENYL-4-[(PHENYLAMINO) CARBONYL]-1H-PYRROL-1-yl]ETHYL]-2,2-DIMETHYL-1,3-DIOXANE-4-ACETATE (ATORVASTATINE CONDENSATION PRODUCT | L-1) - Risk and Safety

(4R-CIS)-1,1-DIMETHYLETHYL-6-[2-[2-(4-FLUOROPHENYL)-5-(1-METHYLETHYL)-3-PHENYL-4-[(PHENYLAMINO) CARBONYL]-1H-PYRROL-1-yl]ETHYL]-2,2-DIMETHYL-1,3-DIOXANE-4-ACETATE (ATORVASTATINE CONDENSATION PRODUCT | L-1) - Reference Information

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(4R-CIS)-1,1-DIMETHYLETHYL-6-[2-[2-(4-FLUOROPHENYL)-5-(1-METHYLETHYL)-3-PHENYL-4-[(PHENYLAMINO) CARBONYL]-1H-PYRROL-1-yl]ETHYL]-2,2-DIMETHYL-1,3-DIOXANE-4-ACETATE (ATORVASTATINE CONDENSATION PRODUCT | L-1) Request for Quotation

(4R-CIS)-1,1-DIMETHYLETHYL-6-[2-[2-(4-FLUOROPHENYL)-5-(1-METHYLETHYL)-3-PHENYL-4-[(PHENYLAMINO) CARBONYL]-1H-PYRROL-1-yl]ETHYL]-2,2-DIMETHYL-1,3-DIOXANE-4-ACETATE (ATORVASTATINE CONDENSATION PRODUCT | L-1)

CAS: 125971-95-1

Molecular Formula: C40H47FN2O5

(4R-CIS)-1,1-DIMETHYLETHYL-6-[2-[2-(4-FLUOROPHENYL)-5-(1-METHYLETHYL)-3-PHENYL-4-[(PHENYLAMINO) CARBONYL]-1H-PYRROL-1-yl]ETHYL]-2,2-DIMETHYL-1,3-DIOXANE-4-ACETATE (ATORVASTATINE CONDENSATION PRODUCT | L-1) - Names and Identifiers

(4R-CIS)-1,1-DIMETHYLETHYL-6-[2-[2-(4-FLUOROPHENYL)-5-(1-METHYLETHYL)-3-PHENYL-4-[(PHENYLAMINO) CARBONYL]-1H-PYRROL-1-yl]ETHYL]-2,2-DIMETHYL-1,3-DIOXANE-4-ACETATE (ATORVASTATINE CONDENSATION PRODUCT | L-1) - Physico-chemical Properties

(4R-CIS)-1,1-DIMETHYLETHYL-6-[2-[2-(4-FLUOROPHENYL)-5-(1-METHYLETHYL)-3-PHENYL-4-[(PHENYLAMINO) CARBONYL]-1H-PYRROL-1-yl]ETHYL]-2,2-DIMETHYL-1,3-DIOXANE-4-ACETATE (ATORVASTATINE CONDENSATION PRODUCT | L-1) - Risk and Safety

(4R-CIS)-1,1-DIMETHYLETHYL-6-[2-[2-(4-FLUOROPHENYL)-5-(1-METHYLETHYL)-3-PHENYL-4-[(PHENYLAMINO) CARBONYL]-1H-PYRROL-1-yl]ETHYL]-2,2-DIMETHYL-1,3-DIOXANE-4-ACETATE (ATORVASTATINE CONDENSATION PRODUCT | L-1) - Reference Information

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(4R-CIS)-1,1-DIMETHYLETHYL-6-[2-[2-(4-FLUOROPHENYL)-5-(1-METHYLETHYL)-3-PHENYL-4-[(PHENYLAMINO) CARBONYL]-1H-PYRROL-1-yl]ETHYL]-2,2-DIMETHYL-1,3-DIOXANE-4-ACETATE (ATORVASTATINE CONDENSATION PRODUCT | L-1)